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PMID: 68998 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A suppressor T cell in the human mixed lymphocyte reaction.

The Journal of experimental medicine ·Vol. 146 ·No. 2 ·1977-08-01 ·Pages 368-80

McMichael AJ, Sasazuki T

Abstract

Lymphocytes from an HLA-B7 DW2 homozygous multiparous woman, J.H., failed to respond in the mixed lymphocyte reaction to lymphocytes from her DW1 homozygous husband, W.H., and certain other homozygous typing cells. J.H. lymphocytes could suppress the response of HLA matched responders to W.H. This effect was shown to be radiosensitive and due to a T cell. The suppressor cell showed antigen specificity.

MeSH Terms
Cells, Cultured Epitopes Female HLA Antigens Histocompatibility Antigens Homozygote Humans Immunologic Techniques Immunosuppression Therapy In Vitro Techniques Lymphocyte Culture Test, Mixed Male T-Lymphocytes/immunology Time Factors
Chemicals
Epitopes HLA Antigens Histocompatibility Antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
McMichael A J
Sasazuki T
References (16)
16 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.146.2.368
Published
1977-08-01
Pages
368-80
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2180765
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.146.2.368 PMC Full Text View journal details
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