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PMID: 6870544 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Monoclonal antibodies against a paramyxovirus isolated from Japanese Sparrow-Hawks.

Archives of virology ·Vol. 76 ·No. 2 ·1983-00-00 ·Pages 145-51

Hoshi S, Mikami T, Nagata K, Onuma M, Izawa H

Abstract

Five monoclonal antibodies against the haemagglutinin-neuraminidase (HN) molecule of Taka virus, a variant of Newcastle disease virus (NDV), were established to compare the antigenicities of several avian paramyxoviruses including NDV. From the results of the cross haemagglutination-inhibition (HI) test with the monoclonal antibodies, the HN molecule of Taka virus seemed to have at least three different antigenic determinants; one was specific for all NDV strains tested, the second was for Taka virus and Komarov strain of NDV and the third was for Taka virus, Komarov strain, Bangor and Yucaipa. Furthermore, the differences in the ratio of HI to neuraminidase-inhibition titers suggested that the separate active sites involved in haemagglutinin and neuraminidase activities might exist at least in close proximity.

MeSH Terms
Animals Antibodies, Monoclonal/immunology Birds/microbiology Hemagglutination Inhibition Tests Neuraminidase/antagonists & inhibitors Newcastle disease virus/immunology
Chemicals
Antibodies, Monoclonal Neuraminidase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hoshi S
Mikami T
Nagata K
Onuma M
Izawa H
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32 references, click to expand
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Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/BF01311698
Published
1983-00-00
Pages
145-51
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01311698 View journal details
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