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PMID: 6859221 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Stimulation of human monocyte/macrophage-derived growth factor (MDGF) production by plasma fibronectin.

The American journal of pathology ·Vol. 111 ·No. 3 ·1983-06-00 ·Pages 367-73

Martin BM, Gimbrone MA, Majeau GR, Unanue ER, Cotran RS

Abstract

Culture supernatants from human peripheral blood monocytes, isolated free of platelet contamination and cultured in the absence of serum, stimulate DNA synthesis and cell growth in Balb/c 3T3 fibroblasts and bovine aortic smooth-muscle cells. Monocytes cultured in serum-free medium for 24 hours with plasma fibronectin, added as either a surface-attached or soluble molecule, secrete significantly increased amounts of growth-promoting activity. Fibronectin also stimulates an increase in intracellular growth factor content and in protein synthesis by monocytes. Both the enhanced growth-promoting activity and protein synthesis are inhibited by cycloheximide. Thus, fibronectin-monocyte interactions may influence the production of growth-promoting activity by monocytes and contribute to fibroblast and smooth-muscle replication in wound healing, chronic inflammation and atherosclerosis.

MeSH Terms
Cell Adhesion Cells, Cultured DNA/biosynthesis Fibronectins/pharmacology Growth Substances/metabolism Humans Macrophages/drug effects,metabolism Monocytes/drug effects,metabolism Stimulation, Chemical
Chemicals
Fibronectins Growth Substances DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Martin B M
Gimbrone M A
Majeau G R
Unanue E R
Cotran R S
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33 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1983-06-00
Pages
367-73
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1916285
Subset
IM
Grants
NHLBI NIH HHS · HL22602 · United States
External Links
PubMed source PMC Full Text View journal details
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