Infectious vaccinia virus recombinants that express hepatitis B virus surface antigen.

Nature ·Vol. 302 ·No. 5908 ·1983-04-07 ·Pages 490-5

Smith GL, Mackett M, Moss B

Abstract

Potential live vaccines against hepatitis B virus have been produced. The coding sequence for hepatitis B virus surface antigen (HBsAg) has been inserted into the vaccinia virus genome under control of vaccinia virus early promoters. Cells infected with these vaccinia virus recombinants synthesize and excrete HBsAg and vaccinated rabbits rapidly produce antibodies to HBsAg.

MeSH Terms

Animals Antibody Formation Chromosome Mapping DNA, Recombinant Gene Expression Regulation Genes Genes, Viral Hepatitis B Surface Antigens/genetics Hepatitis B virus/immunology Molecular Weight Rabbits Vaccination Vaccinia virus/genetics,immunology Viral Vaccines/immunology

Chemicals

DNA, Recombinant Hepatitis B Surface Antigens Viral Vaccines

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Smith G L

Mackett M

Moss B

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/302490a0

Published

1983-04-07

Pages

490-5

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/302490a0 View journal details

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Infectious vaccinia virus recombinants that express hepatitis B virus surface antigen.

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