Home LiteratureArticle Details

PMID: 6824945 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The isolation and amino acid composition of senile plaque core protein.

Brain research ·Vol. 259 ·No. 2 ·1983-01-24 ·Pages 348-52

Allsop D, Landon M, Kidd M

Abstract

A new method has been developed for the isolation of intact senile (neuritic) plaque cores from post-mortem brains of patients with Alzheimer's disease. The plaque cores were found to be insoluble in various protein denaturants. The amino acid composition of the plaque core protein does not resemble that of any known form of amyloid.

MeSH Terms

Aged Alzheimer Disease/metabolism Amino Acids/metabolism Amyloid/metabolism Cerebral Cortex/metabolism Dementia/metabolism Humans Middle Aged Nerve Tissue Proteins/metabolism Neurofibrils/metabolism Neurons/metabolism

Chemicals

Amino Acids Amyloid Nerve Tissue Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Allsop D

Landon M

Kidd M

Article Info

Journal

Brain research

Abbr.

Brain Res

ISSN

0006-8993

DOI

10.1016/0006-8993(83)91273-8

Published

1983-01-24

Pages

348-52

Language

English

Region

Netherlands

NLM ID

0045503

Subset

External Links

PubMed source DOI: 10.1016/0006-8993(83)91273-8 View journal details

Analysis Services

The isolation and amino acid composition of senile plaque core protein.

Contact

WeChat Official Account