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PMID: 6821132 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Similarity of secretory protein I from parathyroid gland to chromogranin A from adrenal medulla.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 19 ·1982-10-00 ·Pages 6056-9

Cohn DV, Zangerle R, Fischer-Colbrie R, Chu LL, Elting JJ, Hamilton JW, Winkler H

Abstract

We have compared the amino acid and carbohydrate compositions, partial amino acid sequences, immunological crossreactivity, and physical properties of secretory protein I of the parathyroid gland and chromogranin A of adrenal gland. This comparison indicates that these proteins are similar molecules. Because secretory protein I is present in secretory granules containing parathormone and is cosecreted with the hormone, and because chromogranin A is contained within chromaffin granules and, likewise, is secreted with the catecholamines, the present observations raise the possibility that this class of protein plays a general role in hormone secretion or storage mechanisms.

MeSH Terms
Adrenal Medulla/analysis Amino Acid Sequence Amino Acids/analysis Animals Calcium-Binding Proteins/isolation & purification Cattle Chromaffin Granules/analysis Chromaffin System/analysis Chromogranin A Chromogranins/isolation & purification Cross Reactions Immunodiffusion Molecular Weight Nerve Tissue Proteins/isolation & purification Parathyroid Glands/metabolism Structure-Activity Relationship
Chemicals
Amino Acids Calcium-Binding Proteins Chromogranin A Chromogranins Nerve Tissue Proteins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Cohn D V
Zangerle R
Fischer-Colbrie R
Chu L L
Elting J J
Hamilton J W
Winkler H
References (30)
30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.19.6056
Published
1982-10-00
Pages
6056-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC347051
Subset
IM
Grants
NIADDK NIH HHS · AM 18323 · United States
External Links
PubMed source DOI: 10.1073/pnas.79.19.6056 PMC Full Text View journal details
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