Secretory component of epithelial cells is a surface receptor for polymeric immunoglobulins.
Epithelial cells of human fetal intestines and of a colonic carcinoma cell line (HT-29) exhibited intracellular and surface binding of polymeric immunoglobulins of IgA and IgM classes; monomeric IgA and IgG did not bind to these cells. Secretory component was identified as the receptor involved in the immunoglobulin binding. This conclusion was confirmed by the following experiments: trypsin abrogated the surface binding of polymeric immunoglobulin, reappearance of surface secretory component (SC) restored immunoglobulin binding; the appearance of SC in developing fetal tissues coincided with their potential to bind polymeric immunoglobulin; anti-SC reagents inhibited the binding of immunoglobulins to epithelial cells; and SC-containing secretory IgA did not bind to the surface of HT-29 cells.
18 references, click to expand
-
Studies on J chain and binding site for secretory component in circulating human B cells.Clin Exp Immunol. 1976 Jul;25(1):50-8 PMID: 62630
-
Intestinal secretion of IgA and IgM: a hypothetical model.Ciba Found Symp. 1977 Apr 26-28;(46):77-113 PMID: 416937
-
Secretory IgM antibodies to Streptococcus mutans in subjects with selective IgA deficiency.Clin Immunol Immunopathol. 1977 Nov;8(3):475-86 PMID: 410569
-
Properties of IgA myeloma proteins isolated rom sera of patients with the hyperviscosity syndrome.J Lab Clin Med. 1977 May;89(5):919-27 PMID: 404374
-
Studies on translocation of immunoglobulins across intestinal epithelium. IV. Evidence for binding of IgA and IgM to secretory component in intestinal epithelium.Gastroenterology. 1977 Dec;73(6):1333-9 PMID: 334623
-
Naturally occurring polymers of IgA lacking J chain.Scand J Immunol. 1976;5(6-7):647-53 PMID: 824715
-
Proportion of human colostral immunoglobulin-A molecules containing the secretory determinant.Immunology. 1970 Feb;18(2):237-43 PMID: 4190418
-
Recombination of the polypeptide chains of a Waldenström's IgM that binds IgG.J Immunol. 1973 Dec;111(6):1699-711 PMID: 4201553
-
Association of S-IgA subunits.Adv Exp Med Biol. 1974;45(0):99-109 PMID: 4137549
-
Studies on human secretory immunoglobulin A. II. Subunit structure.J Immunol. 1972 Mar;108(3):738-47 PMID: 4110988
-
The IgA system. I. Studies of the transport and immunochemistry of IgA in the saliva.J Exp Med. 1966 Apr 1;123(4):615-27 PMID: 4160397
-
Human secretory component. I. Purification of free secretory component from colostrum.Scand J Immunol. 1974;3(5):579-88 PMID: 4214117
-
Stabilization of dissociable IgA2 proteins by secretory component.J Immunol. 1972 Aug;109(2):275-83 PMID: 4625844
-
Immunohistologic localization of immunoglobulins, secretory component, and lactoferrin in the developing human fetus.Proc Soc Exp Biol Med. 1972 Feb;139(2):570-4 PMID: 4550938
-
Increased risistance of immunoglobulin A dimers to proteolytic degradation after binding of secretory component.J Immunol. 1975 Jan;114(1 Pt 2):284-6 PMID: 1090649
-
Secretory component deficiency. A disorder of the IgA immune system.N Engl J Med. 1976 Feb 12;294(7):351-6 PMID: 1107842
-
Synthesis of secretory component by human colon cancer cells.Scand J Immunol. 1976;5(3):263-8 PMID: 1273516
-
Localization of b markers, alpha-chain and SC of SIgA in epithelial cells lining Lieberkühn crypts.J Immunol. 1971 Jan;106(1):286-8 PMID: 5543722
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