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PMID: 6814009 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Strong association between an HLA-DR antigen and thyroid carcinoma.

Tissue antigens ·Vol. 20 ·No. 2 ·1982-08-00 ·Pages 155-8

Panza N, Del Vecchio L, Maio M, De Felice M, Lombardi G, Minozzi M, Zappacosta S

Abstract

A group of 20 patients affected with thyroid carcinoma, all from Southern Italy, was typed for HLA-A, -B, -C and -DR antigens. Sixteen of them (80%) typed for DR1, while in the control group (120 unrelated healthy individuals from the same region) only 22 (18.3%) shared the same antigen (chi 2 = 32.96). The data indicate a highly significant association between the HLA-DR1 gene and the thyroid carcinoma.

MeSH Terms

Adenocarcinoma/epidemiology,genetics,immunology Carcinoma, Papillary/epidemiology,genetics,immunology Female Genes, MHC Class II HLA Antigens/genetics HLA-B Antigens HLA-C Antigens HLA-DR Antigens Histocompatibility Antigens Class II/immunology Histocompatibility Testing Humans Italy Male Thyroid Neoplasms/epidemiology,genetics,immunology

Chemicals

HLA Antigens HLA-B Antigens HLA-C Antigens HLA-DR Antigens Histocompatibility Antigens Class II

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Panza N

Del Vecchio L

Maio M

De Felice M

Lombardi G

Minozzi M

Zappacosta S

Article Info

Journal

Tissue antigens

Abbr.

Tissue Antigens

ISSN

0001-2815

DOI

10.1111/j.1399-0039.1982.tb00340.x

Published

1982-08-00

Pages

155-8

Language

English

Region

England

NLM ID

0331072

Subset

External Links

PubMed source DOI: 10.1111/j.1399-0039.1982.tb00340.x View journal details

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