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PMID: 6814007 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

HLA haplotype study of 53 juvenile insulin-dependent diabetic (I.D.D.) families.

Tissue antigens ·Vol. 20 ·No. 2 ·1982-08-00 ·Pages 123-40

Contu L, Deschamps I, Lestradet H, Hors J, Schmid M, Busson M, Benajam A, Marcelli-Barge A, Dausset J

Abstract

R4 heterozygotes was observed. By contrast, the observed frequency of patients homozygous for DR3 or DR4 was not increased, but even slightly decreased. The data support a model of inheritance comprising at least two closely linked specifically "diabetic" loci (most of the time marked by B18, BfF1, DR3 and B15, BfS, DR4) and a non-specifically "diabetic" haplotype favouring auto-immunisation (most of the time marked by B8, BfS, DR3). This model is discussed in the light of the presented data and of those of the literature.

MeSH Terms

Adolescent Adult Alleles Child Chromosome Mapping Diabetes Mellitus, Type 1/drug therapy,epidemiology,genetics Disease Susceptibility Female Gene Frequency Genes, MHC Class II Genetic Linkage HLA Antigens/genetics HLA-B Antigens HLA-DR Antigens Haploidy Humans Insulin/therapeutic use Male Paris

Chemicals

HLA Antigens HLA-B Antigens HLA-DR Antigens Insulin

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Contu L

Deschamps I

Lestradet H

Hors J

Schmid M

Busson M

Benajam A

Marcelli-Barge A

Dausset J

Article Info

Journal

Tissue antigens

Abbr.

Tissue Antigens

ISSN

0001-2815

DOI

10.1111/j.1399-0039.1982.tb00335.x

Published

1982-08-00

Pages

123-40

Language

English

Region

England

NLM ID

0331072

Subset

External Links

PubMed source DOI: 10.1111/j.1399-0039.1982.tb00335.x View journal details

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HLA haplotype study of 53 juvenile insulin-dependent diabetic (I.D.D.) families.

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