Home LiteratureArticle Details
PMID: 6806175 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Induction of resistance to tuberculosis in mice with defined components of mycobacteria and with some unrelated materials.

Immunology ·Vol. 46 ·No. 2 ·1982-06-00 ·Pages 297-305

Ribi E, Granger DL, Milner KC, Yamamoto K, Strain SM, Parker R, Smith RW, Brehmer W, Azuma I

Abstract

Factors contributing to protection against experimental tuberculosis have been studied with refined and well characterized fractions from mycobacteria and with certain unrelated antigens. Mice were vaccinated intravenously with various combinations of materials presented on minute oil droplets in saline emulsions and were later challenged by aerosol. The minimal composition of an effective vaccine was P3 (a trehalose mycolate similar to cord factor) plus an antigen, which could be tuberculoprotein, or a low-molecular-weight tuberculin-active peptide, or unrelated antigen such as bovine serum albumin or bacterial endotoxin. Development of a hypersensitivity granuloma in the lungs appeared to be essential to protection in this laboratory model.

MeSH Terms
Animals BCG Vaccine Bacteria/immunology Bacterial Proteins/immunology Cell Migration Inhibition Cord Factors/immunology Granuloma/immunology Hypersensitivity, Delayed Lung Diseases/immunology Macrophages/immunology Male Mice Mycobacterium tuberculosis Peptides/immunology Serum Albumin, Bovine/immunology Tuberculin/immunology Tuberculosis, Pulmonary/immunology,prevention & control
Chemicals
BCG Vaccine Bacterial Proteins Cord Factors Peptides Tuberculin tuberculin-active protein, Mycobacterium tuberculoprotein, Mycobacterium tuberculosis Serum Albumin, Bovine
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Ribi E
Granger D L
Milner K C
Yamamoto K
Strain S M
Parker R
Smith R W
Brehmer W
Azuma I
References (23)
23 references, click to expand
  1. Biologically active components from mycobacterial cell walls. I. Isolation and composition of cell wall skeleton and component P3.
    J Natl Cancer Inst. 1974 Jan;52(1):95-101 PMID: 4590014
  2. Inhibition of pulmonary granuloma formation in mice by treatment with Mycobacterial protoplasm and immuno-suppressants and its relation to protection against aerosol infection with virulent Mycobacterium tuberculosis.
    Zentralbl Bakteriol Mikrobiol Hyg A. 1981;250(1-2):127-41 PMID: 6797153
  3. Electron microscopically revealed structural elements of Bacterium tularense and their in vitro and in vivo role in immunologic reactions.
    J Immunol. 1955 Jul;75(1):7-14 PMID: 13242796
  4. [Immunobiology of tuberculosis].
    Naturwissenschaften. 1976 Apr;63(4):185-9 PMID: 1085918
  5. Factors influencing protection against experimental tuberculosis in mice by heat-stable cell wall vaccines.
    J Bacteriol. 1966 Oct;92(4):869-79 PMID: 5332873
  6. Cellular reaction in the footpad and draining lymph nodes of mice induced by mycobacterial fractions and BCG bacilli.
    Infect Immun. 1971 Sep;4(3):245-55 PMID: 4949489
  7. Delayed hypersensitivity and granulomatous response after immunization with protein antigens associated with a mycobacterial glycolipid and oil droplets.
    J Immunol. 1976 Feb;116(2):482-8 PMID: 55442
  8. Migration inhibitory factor and type II interferon in the circulation of mice sensitized with mycobacterial components.
    J Immunol. 1975 Jan;114(1 Pt 2):354-9 PMID: 1090652
  9. Granuloma formation around schistosome eggs as a manifestation of delayed hypersensitivity.
    Am J Pathol. 1967 Nov;51(5):735-56 PMID: 6054847
  10. Immune response to sheep red blood cells in mice pretreated with mycobacterial fractions.
    Infect Immun. 1971 Sep;4(3):256-63 PMID: 4949490
  11. Macrophage Migration Inhibition Studies with Cells from Mice Vaccinated with Cell Walls of Mycobacterium bovis BCG: Characterization of the Experimental System.
    Infect Immun. 1970 Jun;1(6):587-94 PMID: 16557780
  12. Effectiveness of cell walls of Mycobacterium bovis strain BCG administered by various routes and in different adjuvants in protecting mice against airborne infection with Mycobacterium tuberculosis strain H37Rv.
    Am Rev Respir Dis. 1969 Feb;99(2):242-8 PMID: 4975012
  13. An apparatus for airborne infection of mice.
    Proc Soc Exp Biol Med. 1952 May;80(1):105-10 PMID: 14930088
  14. EXTRACTION AND PURIFICATION OF ENDOTOXIN FROM ENTEROBACTERIACEAE: A COMPARISON OF SELECTED METHODS AND SOURCES.
    J Bacteriol. 1964 Feb;87:391-400 PMID: 14151062
  15. Granuloma formation induced in mice by chemically defined mycobacterial fractions.
    J Bacteriol. 1969 Oct;100(1):95-102 PMID: 4981067
  16. A possible relationship between delayed hypersensitivity and cell-mediated immunity.
    Am Rev Respir Dis. 1975 Apr;111(4):373-7 PMID: 47728
  17. Immunologic events in experimental hypersensitivity granulomas.
    Am J Pathol. 1973 Jun;71(3):349-64 PMID: 4123737
  18. Effects of pretreatment of mice with BCG cell walls in saline on subsequent vaccination with BCG oil droplet vaccine.
    Cell Immunol. 1974 Oct;14(1):52-65 PMID: 4219589
  19. Isolation of tuberculin active peptides from cell wall fraction of human tubercle bacillus strain Aoyama B.
    Jpn J Microbiol. 1969 Jun;13(2):220-2 PMID: 4980415
  20. Biologically active components from mycobacterial cell walls. IV. Protection of mice against aerosol infection with virulent mycobacterium tuberculosis.
    Cell Immunol. 1975 Mar;16(1):1-10 PMID: 803876
  21. Moieties of mycobacterial mycolates required for inducing granulomatous reactions.
    Cell Immunol. 1978 Jun;38(1):14-24 PMID: 667954
  22. Separation of the mixture of trehalose 6,6'-dimycolates comprising the mycobacterial glycolipid fraction, "P3".
    Biochem Biophys Res Commun. 1977 Jul 25;77(2):449-56 PMID: 409398
  23. The chemistry of cord factor, a toxic glycolipid of M. tuberculosis.
    Bibl Tuberc. 1956;(10):149-83 PMID: 13341885
Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1982-06-00
Pages
297-305
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1555377
Subset
IM
Grants
NCI NIH HHS · N01-CP-45609 · United States
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2