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PMID: 6800538 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Circadian variation in disease activity in rheumatoid arthritis.

British medical journal (Clinical research ed.) ·Vol. 284 ·No. 6315 ·1982-02-20 ·Pages 551-4

Harkness JA, Richter MB, Panayi GS, Van de Pette K, Unger A, Pownall R, Geddawi M

Abstract

Disease activity in rheumatoid arthritis as measured by repeated estimation of joint pain, stiffness, articular index, and grip strength was shown to have a circadian rythm, maximal activity being seen between 0200 and 0400 and minimal activity in the early afternoon. This variation in disease activity may be related to circadian alterations in immune and inflammatory responses (such as immune complexes and neutrophil function) dependent on alterations in circulating concentrations of steroids. The circadian variation in disease activity has important implications in assessment of patients, prescription of drugs, and performance of drug trials.

MeSH Terms

Adult Aged Arthritis, Rheumatoid/blood,immunology,physiopathology Circadian Rhythm Complement Activating Enzymes/metabolism Complement C1q Female Hand/physiopathology Humans Hydrocortisone/blood Joints/physiopathology Leukocyte Count Male Middle Aged Neutrophils Pain/physiopathology

Chemicals

Complement C1q Complement Activating Enzymes Hydrocortisone

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Harkness J A

Richter M B

Panayi G S

Van de Pette K

Unger A

Pownall R

Geddawi M

References (11)

11 references, click to expand

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Circadian variations in the signs and symptoms of rheumatoid arthritis and in the therapeutic effectiveness of flurbiprofen at different times of day.
Br J Clin Pharmacol. 1981 May;11(5):477-84 PMID: 7272159
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Article Info

Journal

British medical journal (Clinical research ed.)

Abbr.

Br Med J (Clin Res Ed)

ISSN

0267-0623

DOI

10.1136/bmj.284.6315.551

Published

1982-02-20

Pages

551-4

Language

English

Region

England

NLM ID

8302911

PMCID

PMC1496102

Subset

External Links

PubMed source DOI: 10.1136/bmj.284.6315.551 PMC Full Text

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