Copper induction of translatable metallothionein messenger RNA.

Bioscience reports ·Vol. 1 ·No. 10 ·1981-10-00 ·Pages 793-800

Mercer JF, Lazdins I, Stevenson T, Camakaris J, Danks DM

Abstract

Copper chloride injection of rats resulted in a 4.5- to 9-fold increase in translatable metallothionein messenger RNA in the liver. Metallothionein in the translation products was identified on the basis of high cysteine and serine incorporation and absence of leucine incorporation as well as comigration with authentic zinc-induced rat-liver metallothionein on SDS-polyacrylamide gels.

MeSH Terms

Animals Copper/pharmacology Cysteine/metabolism Electrophoresis, Polyacrylamide Gel Leucine/metabolism Liver/drug effects,metabolism Male Metalloproteins/biosynthesis Metallothionein/biosynthesis Protein Biosynthesis RNA, Messenger/biosynthesis Rats Rats, Inbred Strains Serine/metabolism Sulfates/pharmacology Zinc/pharmacology Zinc Sulfate

Chemicals

Metalloproteins RNA, Messenger Sulfates Serine Zinc Sulfate Copper Metallothionein Leucine Zinc Cysteine cupric chloride

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Mercer J F

Lazdins I

Stevenson T

Camakaris J

Danks D M

Article Info

Journal

Bioscience reports

Abbr.

Biosci Rep

ISSN

0144-8463

DOI

10.1007/BF01114802

Published

1981-10-00

Pages

793-800

Language

English

Region

England

NLM ID

8102797

Subset

External Links

PubMed source DOI: 10.1007/BF01114802 View journal details

Analysis Services

Copper induction of translatable metallothionein messenger RNA.

Contact

WeChat Official Account