UK-37, 248, a novel, selective thromboxane synthetase inhibitor with platelet anti-aggregatory and anti-thrombotic activity.

Animals Arachidonic Acid Arachidonic Acids/pharmacology Cattle Cyclooxygenase Inhibitors Dogs Humans Imidazoles/pharmacology Indomethacin/pharmacology Lung/metabolism,pathology Male Oxidoreductases/antagonists & inhibitors Platelet Aggregation/drug effects Rabbits Sheep Thromboembolism/drug therapy Thromboxane B2/biosynthesis Thromboxane-A Synthase/antagonists & inhibitors

Arachidonic Acids Cyclooxygenase Inhibitors Imidazoles dazoxiben Arachidonic Acid Thromboxane B2 Oxidoreductases Thromboxane-A Synthase Indomethacin