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PMID: 6793567 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Suppression of calcium-induced removal of the Z-line by a thiol-protease inhibitor, E-64-c.

Journal of biochemistry ·Vol. 90 ·No. 1 ·1981-07-00 ·Pages 283-5

Ishiura S, Nonaka I, Sugita H

Abstract

A new thiol-protease inhibitor, E-64-c (N-[N-(L-3-carboxyoxirane-2-carbonyl)-L-leucyl]-isoamylamine), specifically suppressed the disappearance of the Z-line terminal by calcium in rat soleus muscle. This results suggests that calcium-activated neutral protease (CANP) may be involved in such calcium-mediated degeneration of myofilaments.

MeSH Terms

Animals Calcimycin/pharmacology Calcium/pharmacology Leucine/analogs & derivatives,pharmacology Muscles/drug effects,physiology Myofibrils/drug effects,physiology Rats

Chemicals

Calcimycin N-(N-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine Leucine Calcium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Ishiura S

Nonaka I

Sugita H

Article Info

Journal

Journal of biochemistry

Abbr.

J Biochem

ISSN

0021-924X

Published

1981-07-00

Pages

283-5

Language

English

Region

England

NLM ID

0376600

Subset

External Links

PubMed source View journal details

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Suppression of calcium-induced removal of the Z-line by a thiol-protease inhibitor, E-64-c.

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