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PMID: 6793514 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Experimental retrograde pyelonephritis and cystitis induced in rabbits by a group D Streptococcus sp.: serum antibody assay by a hemagglutination test.

Infection and immunity ·Vol. 33 ·No. 3 ·1981-09-00 ·Pages 647-50

Desnottes JF, Bensman A, Ave-Virat A, Fontaine JL

Abstract

Experimental models of urinary tract infection caused by a group D Streptococcus sp. in rabbits are described: retrograde pyelonephritis was induced by injecting 10(9) group D streptococci into the renal pelvis and obstructing the ureter by ligature for 24 h; cystitis was induced by injecting 5.10(9) group D streptococci through a transurethral catheter. The animals were observed for 3 months. Microbiological data from the urine and from the renal parenchyma were well correlated in 12 of 14 animals. A hemagglutination test for titration of serum antibodies in these infected rabbits is described. Before the beginning of experimentation, hemagglutination titers for all animals were below 160. During experimentation, titers for rabbits with cystitis were always below 640; in those with pyelonephritis, the highest titer was much greater than 640. These results show a positive correlation between serum antibody levels and the localization of urinary tract infection.

MeSH Terms

Animals Antibodies, Bacterial/analysis Bacteriuria Cystitis/etiology,immunology Disease Models, Animal Enterococcus faecalis/immunology Hemagglutination Tests Male Pyelonephritis/etiology,immunology Rabbits Streptococcal Infections/immunology

Chemicals

Antibodies, Bacterial

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Desnottes J F

Bensman A

Ave-Virat A

Fontaine J L

References (21)

21 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.33.3.647-650.1981

Published

1981-09-00

Pages

647-50

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC350756

Subset

External Links

PubMed source DOI: 10.1128/iai.33.3.647-650.1981 PMC Full Text View journal details

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Experimental retrograde pyelonephritis and cystitis induced in rabbits by a group D Streptococcus sp.: serum antibody assay by a hemagglutination test.

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