Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains.
T cells from strains responder to the antigen poly(Glu40 Ala60) (GA) were depleted of alloreactive cells by bromo-deoxyuridine and light treatment, and were subsequently primed in vitro in GA presented by allogeneic macrophages from nonresponder strains. Antigen-specific secondary proliferative responses restricted by allogeneic Ia molecules of the macrophages were obtained in all strain combinations tested. These data indicate that Ir gene-controlled nonresponsiveness cannot be the result of a failure of antigen presentation.
14 references, click to expand
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Nature of T cell-macrophage interaction in helper cell induction in vitro. III. Responsiveness of T cells differentiating in irradiation or allophenic chimeras depends on the genotype of the host.J Immunol. 1980 Jun;124(6):2656-64 PMID: 6768800
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Gene complementation. Neither Ir-GLphi gene need be present in the proliferative T cell to generate an immune response to Poly(Glu55Lys36Phe9)n.J Exp Med. 1980 Jun 1;151(6):1452-67 PMID: 6770025
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Fine specificity analysis with monoclonal antibodies of antigens controlled by the major histocompatibility complex and by the Qa/TL region in mice.Immunol Rev. 1979;47:175-206 PMID: 398326
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Genetic control of T-cell proliferative responses to poly(glu40ala60) and poly(glu51lys34tyr15): subregion-specific inhibition of the responses with monoclonal Ia antibodies.Immunogenetics. 1980;11(6):617-28 PMID: 6086092
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Nature of the antigenic complex recognized by T lymphocytes: specific sensitization by antigens associated with allogeneic macrophages.Proc Natl Acad Sci U S A. 1977 May;74(5):2104-8 PMID: 68474
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The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens.J Exp Med. 1977 Aug 1;146(2):361-7 PMID: 301550
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T cells specific for hapten-modified self are precommitted for self major histocompatibility complex antigens before encounter with the hapten.J Exp Med. 1978 Apr 1;147(4):1065-77 PMID: 306404
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A hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes.J Immunol. 1978 Jun;120(6):1809-12 PMID: 77879
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Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.Proc Natl Acad Sci U S A. 1978 May;75(5):2439-42 PMID: 307765
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The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression.J Exp Med. 1978 Dec 1;148(6):1510-22 PMID: 102728
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H-2 complementation in anti-H-Y cytotoxic T-cell responses can occur in chimeric mice.Proc Natl Acad Sci U S A. 1978 Dec;75(12):6207-10 PMID: 310553
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Influence of thymus genotype on acquisition of responsiveness in delayed-type hypersensitivity.Scand J Immunol. 1979;9(1):29-38 PMID: 105404
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Genetic control of the immune response to collagen. II. Antibody responses produced in fetal liver restored radiation chimeras and thymus reconstituted F1 hybrid nude mice.J Exp Med. 1979 Sep 19;150(3):646-52 PMID: 113479
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Cellular and genetic control of antibody responses. VI. Expression of Ir gene function by H-2a accessory cells, but not H-2a T or B cells in responses to TNP-(T,G)-A--L.J Immunol. 1979 Dec;123(6):2823-9 PMID: 115922
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