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PMID: 6789348 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Effects of alcohol on the despair response to peer separation in rhesus monkeys.

Psychopharmacology ·Vol. 73 ·No. 4 ·1981-00-00 ·Pages 307-10

Kraemer GW, Lin DH, Moran EC, McKinney WT

Abstract

In humans, alcoholism and depression are often interrelated. This study examines the effects of alcohol on peer separation-induced despair in rhesus monkeys, a proposed nonhuman primate model of depression. Alcohol, at three different dose levels, or placebo was administered to rhesus monkeys undergoing repeated peer separation. Low-dose alcohol (1 g/kg/day) decreased separation-induced despair, whereas high-dose alcohol (3 g/kg/day) exacerbated the despair response as compared to placebo. This biphasic effect of alcohol on the despair response may be analogous to similar effects of alcohol on depression in humans.

MeSH Terms
Animals Anxiety, Separation/psychology Ataxia/chemically induced Dose-Response Relationship, Drug Ethanol/administration & dosage,pharmacology Female Humans Macaca mulatta Male Placebos Social Behavior/drug effects Tremor/chemically induced
Chemicals
Placebos Ethanol
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kraemer G W
Lin D H
Moran E C
McKinney W T
References (12)
12 references, click to expand
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF00426455
Published
1981-00-00
Pages
307-10
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
Grants
PHS HHS · 10570 · United States
NIGMS NIH HHS · GM07058 · United States
NIMH NIH HHS · MH 21892 · United States
External Links
PubMed source DOI: 10.1007/BF00426455 View journal details
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