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PMID: 6788886 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The xid gene controls Ia.W39-associated immune response gene function.

The Journal of experimental medicine ·Vol. 153 ·No. 5 ·1981-05-01 ·Pages 1113-23

Rosenwasser LJ, Huber BT

Abstract

Immune response (Ir) genes are encoded for by the I region of the major histocompatibility complex (MHC). A class of serologically defined specificities, Ia antigens, is also encoded for by genes within this region. A new Ia specificity, Ia.W39, has recently been defined. It is private for I-Ab and its expression is controlled by a gene on the X-chromosome. Using different approaches, the role of Ia.W39 in the immune response of H-2b mice to beef insulin was examined in a macrophage-dependent T cell proliferation assay. It was found that beef insulin-related Ir gene function was associated with the expression of Ia.W39 by antigen-presenting macrophages and that control of this Ir gene function was X-linked (xid gene).

MeSH Terms
Animals Cattle Cell Division Female Genes, MHC Class II Histocompatibility Antigens Class II/immunology Insulin/pharmacology Male Mice Sex Chromosomes T-Lymphocytes/cytology X Chromosome
Chemicals
Histocompatibility Antigens Class II Insulin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rosenwasser L J
Huber B T
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25 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.153.5.1113
Published
1981-05-01
Pages
1113-23
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2186148
Subset
IM
Grants
NIAID NIH HHS · AI-14910 · United States
NCI NIH HHS · CA-24530 · United States
External Links
PubMed source DOI: 10.1084/jem.153.5.1113 PMC Full Text View journal details
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