Isoenzymes of membrane-bound beta-glucosidase of human spleen.

The Biochemical journal ·Vol. 185 ·No. 2 ·1980-02-01 ·Pages 541-3

Yaqoob M, Carroll M

Abstract

Normal human spleen contains two forms of membrane-bound beta-glucosidase, distinguishable by their thermostability and kinetic properties. The spleen from a patient with adult Gaucher's disease was deficient in the major, thermolabile, form of the enzyme.

MeSH Terms

Cell Membrane/enzymology Gaucher Disease/enzymology Glucosidases/metabolism Hot Temperature Humans Isoenzymes/metabolism Kinetics Spleen/enzymology beta-Glucosidase/metabolism

Chemicals

Isoenzymes Glucosidases beta-Glucosidase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Yaqoob M

Carroll M

References (10)

10 references, click to expand

Identity of 'acid' beta-glucosidase and glucocerebrosidase in human spleen.
Biochem J. 1973 Nov;136(3):721-9 PMID: 4780697
Solubilization of glucocerebrosidase from human placenta and demonstration of a phospholipid requirement for its catalytic activity.
Biochem Biophys Res Commun. 1976 Aug 23;71(4):1048-53 PMID: 971299
Cell-specific differences in membrane beta-glucosidase from normal and Gaucher cells.
Biochim Biophys Acta. 1977 Feb 9;480(2):442-9 PMID: 13844
Steroid beta-D-glucosidase in steer liver and kidney.
Can J Biochem. 1977 Jan;55(1):41-2 PMID: 837245
The diagnosis of Gaucher's disease in liver using 4-methylumbelliferyl-beta-D-glucopyranoside.
Clin Chim Acta. 1977 Feb 15;75(1):155-61 PMID: 14796
Acid beta-glucosidase and the diagnosis of Gaucher's disease in liver and spleen.
Clin Chim Acta. 1978 Aug 1;87(3):433-40 PMID: 28186
Gaucher disease: isolation and comparison of normal and mutant glucocerebrosidase from human spleen tissue.
Proc Natl Acad Sci U S A. 1978 Aug;75(8):3970-3 PMID: 29293
Activation of membrane-bound glucosylceramide: beta-glucosidase in fibroblasts cultured from normal and glucosylceramidotic human skin.
J Biol Chem. 1979 May 10;254(9):3521-5 PMID: 429368
Synthesis and processing of protein-linked oligosaccharides in vivo.
J Biol Chem. 1979 Jun 10;254(11):4568-76 PMID: 220252
METABOLISM OF GLUCOCEREBROSIDES. II. EVIDENCE OF AN ENZYMATIC DEFICIENCY IN GAUCHER'S DISEASE.
Biochem Biophys Res Commun. 1965 Jan 18;18:221-5 PMID: 14282020

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1850541

Published

1980-02-01

Pages

541-3

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1161386

Subset

External Links

PubMed source DOI: 10.1042/bj1850541 PMC Full Text View journal details

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Isoenzymes of membrane-bound beta-glucosidase of human spleen.

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