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PMID: 6769059 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

In vitro polymerization of glial fibrillary acidic (GFA) protein extracted from multiple sclerosis (MS) brain.

Neurochemical research ·Vol. 5 ·No. 3 ·1980-03-00 ·Pages 247-55

Lucas CV, Bensch KG, Eng LF

Abstract

Aqueous extracts of multiple sclerosis plaques were used for reaggregation studies of filamentous proteins. Filament formation as observed by electron microscopy was dependent on temperature, pH, and energy. The major protein component in the filaments had chemical and immunological properties of the glial fibrillary acidic protein.

MeSH Terms
Brain Chemistry Chemical Phenomena Chemistry Electrophoresis, Polyacrylamide Gel Glial Fibrillary Acidic Protein Guanosine Triphosphate Humans Immunodiffusion Macromolecular Substances Microscopy, Electron Molecular Weight Multiple Sclerosis/metabolism Nerve Tissue Proteins/isolation & purification,metabolism Neuroglia/analysis Radioimmunoassay/methods
Chemicals
Glial Fibrillary Acidic Protein Macromolecular Substances Nerve Tissue Proteins Guanosine Triphosphate
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lucas C V
Bensch K G
Eng L F
References (13)
13 references, click to expand
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Article Info
Journal
Neurochemical research
Abbr.
Neurochem Res
ISSN
0364-3190
DOI
10.1007/BF00964613
Published
1980-03-00
Pages
247-55
Language
English
Region
United States
NLM ID
7613461
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00964613 View journal details
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