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PMID: 6757866 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Identification of two erythromycin resistance mutations in the mitochondrial gene coding for the large ribosomal RNA in yeast.

Nucleic acids research ·Vol. 10 ·No. 21 ·1982-11-11 ·Pages 6571-7

Sor F, Fukuhara H

Abstract

Two independent erythromycin resistance mutations, ER514 and ER221, have been identified in the mitochondrial gene coding for the 21S ribosomal RNA. The two mutations were found to be identical, corresponding to a A to G transition at the nucleotide position 1951 of the ribosomal RNA gene. In the secondary structure model of the ribosomal RNA, the ER resistance site is found at the proximity of the chloramphenicol resistance sites located about 500 bases downstream.

MeSH Terms
Animals Base Sequence Chloramphenicol/pharmacology DNA, Mitochondrial/genetics Drug Resistance Erythromycin/pharmacology Genes Mice Mutation Nucleic Acid Conformation RNA, Ribosomal/genetics Saccharomyces cerevisiae/drug effects,genetics Species Specificity
Chemicals
DNA, Mitochondrial RNA, Ribosomal Erythromycin Chloramphenicol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sor F
Fukuhara H
References (22)
22 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/10.21.6571
Published
1982-11-11
Pages
6571-7
Language
English
Region
England
NLM ID
0411011
PMCID
PMC326949
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/10.21.6571 PMC Full Text View journal details
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