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PMID: 6755052 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Hemodynamic and hormonal responses to 8-arginine-vasopressin in healthy man: effects of indomethacin.

Klinische Wochenschrift ·Vol. 60 ·No. 19 ·1982-10-01 ·Pages 1234-9

Glänzer K, Prüssing B, Düsing R, Kramer HJ

Abstract

Previous investigations suggest that in a normotensive organism the vasopressor effect of 8-arginine-vasopressin (AVP) is very effectively buffered by cardiovascular reflex mechanisms. Exogenous AVP administration shows only small, transient increases in blood pressure in spite of continued AVP-infusion and high plasma AVP concentrations. The present study aims to clarify the mechanism of the observed transient blood pressure elevations which are often referred to as "tachyphylaxis". Our results in healthy subjects show a two phase response to exogenous AVP: an initial phase which is characterized by cardiac reflex mechanisms and a second phase during which a normalisation of the elevated total peripheral resistance occurs. Inhibition of prostaglandin synthesis with indomethacin almost completely attenuates this vascular counterregulation to exogenous AVP, thus providing evidence that a prostaglandin mediated vasodilation in response to AVP may be the underlying mechanism for "vasopressin tachyphylaxis". The role of the renin-angiotensin-system and the importance of different regional hemodynamic effects of AVP are discussed.

MeSH Terms
Adult Arginine Vasopressin/pharmacology Cardiac Output/drug effects Female Heart Rate/drug effects Hemodynamics/drug effects Humans Indomethacin/pharmacology Male Prostaglandins/biosynthesis Renin/blood Stroke Volume/drug effects Vascular Resistance/drug effects
Chemicals
Prostaglandins Arginine Vasopressin Renin Indomethacin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Glänzer K
Prüssing B
Düsing R
Kramer H J
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29 references, click to expand
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Article Info
Journal
Klinische Wochenschrift
Abbr.
Klin Wochenschr
ISSN
0023-2173
DOI
10.1007/BF01716729
Published
1982-10-01
Pages
1234-9
Language
English
Region
Germany
NLM ID
2985205R
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01716729
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