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PMID: 6754617 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Chemotaxis of human neutrophils and monocytes induced by Cryptococcus neoformans.

Infection and immunity ·Vol. 38 ·No. 1 ·1982-10-00 ·Pages 380-2

Diamond RD, Erickson NF

Abstract

Chemotaxis of human neutrophils and monocytes was stimulated by sera activated with greater than or equal to 1.25 x 10(6) Cryptococcus neoformans. Leukocytes from five renal transplant recipients had depressed chemotactic responses to C. neoformans-activated sera when compared with normal subjects (P less than 0.05). Concentrations of cryptococcal capsular polysaccharide less than 1 mg/ml failed to generate chemotactic factors from sera.

MeSH Terms

Chemotactic Factors/physiology Chemotaxis, Leukocyte Cryptococcus/physiology Cryptococcus neoformans/physiology Humans Hydrocortisone/pharmacology Immunosuppression Therapy Kidney Transplantation Lymphoma/blood Monocytes/physiology Neutrophils/physiology Polysaccharides, Bacterial/physiology

Chemicals

Chemotactic Factors Polysaccharides, Bacterial Hydrocortisone

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Diamond R D

Erickson N F

References (13)

13 references, click to expand

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Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor.
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Ann Intern Med. 1974 Feb;80(2):176-81 PMID: 4811791
The role of the classical and alternate complement pathways in host defenses against Cryptococcus neoformans infection.
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The selective eosinophil chemotactic activity of histamine.
J Exp Med. 1975 Dec 1;142(6):1462-76 PMID: 450
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Massive antigenemia during disseminated cryptococcosis.
Mayo Clin Proc. 1980 Aug;55(8):513-5 PMID: 7401694
Monocyte-mediated serum-independent damage to hyphal and pseudohyphal forms of Candida albicans in vitro.
J Clin Invest. 1981 Jan;67(1):173-82 PMID: 6256411
[Inhibition of leukocyte migration in vitro by a capsular polyoside of Torulopsis (Cryptococcus) neoformans].
Ann Inst Pasteur (Paris). 1951 Dec;81(6):674-6 PMID: 14933889
Natural host resistance to infection with Cryptococcus neoformans. I. The effect of the properdin system on the experimental disease.
J Infect Dis. 1961 Sep-Oct;109:147-53 PMID: 13896119
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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.38.1.380-382.1982

Published

1982-10-00

Pages

380-2

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC347742

Subset

Grants

NIAID NIH HHS · AI15338 · United States

External Links

PubMed source DOI: 10.1128/iai.38.1.380-382.1982 PMC Full Text View journal details

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Chemotaxis of human neutrophils and monocytes induced by Cryptococcus neoformans.

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