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PMID: 675252 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genetic basis of XX male syndrome and XX true hermaphroditism: evidence in the dog.

Science (New York, N.Y.) ·Vol. 201 ·No. 4356 ·1978-08-18 ·Pages 644-6

Selden JR, Wachtel SS, Koo GC, Haskins ME, Patterson DF

Abstract

Serological analysis of white blood cells from the members of a family of American cocker spaniels indicates that a form of abnormal sexual development, in which individuals with a female karyotype have testes or ovotestes, is caused by anomalous transmission of male-determining H-Y genes.

MeSH Terms

Animals Cell Differentiation Disorders of Sex Development/immunology,veterinary Dog Diseases/genetics Dogs Female Genes Genetic Linkage Histocompatibility Antigens/genetics Leukocytes/immunology Male Ovary/growth & development Testis/growth & development Y Chromosome/immunology

Chemicals

Histocompatibility Antigens

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Selden J R

Wachtel S S

Koo G C

Haskins M E

Patterson D F

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.675252

Published

1978-08-18

Pages

644-6

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.675252 View journal details

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Genetic basis of XX male syndrome and XX true hermaphroditism: evidence in the dog.

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