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PMID: 6722269 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Delayed rectification in the cardiac Purkinje fiber is not activated by intracellular calcium.

Biophysical journal ·Vol. 45 ·No. 4 ·1984-04-00 ·Pages 837-9

Kass RS

Abstract

This study was designed to test the hypothesis that an outward current (Ix) responsible for action potential repolarization in the cardiac Purkinje fiber is activated by intracellular calcium (Cai). Pharmacological probes were combined with the measurement of membrane current and contractile activity under voltage clamp conditions. Experiments were designed to examine properties of Ix that have previously linked activation of this current to changes in Cai. The independence of Ix from Cai was demonstrated for each case tested. Thus, the results of these experiments support the view that Ix is not a calcium-activated current.

MeSH Terms

Action Potentials/drug effects Animals Calcium/metabolism Cattle Dogs Gallopamil/pharmacology Heart Conduction System/physiology Myocardial Contraction/drug effects Purkinje Fibers/drug effects,physiology Ventricular Function

Chemicals

Gallopamil Calcium

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Kass R S

References (14)

14 references, click to expand

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The ionic basis of concentration-related effects of noradrenaline on the action potential of calf cardiac purkinje fibres.
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Article Info

Journal

Biophysical journal

Abbr.

Biophys J

ISSN

0006-3495

DOI

10.1016/S0006-3495(84)84227-7

Published

1984-04-00

Pages

837-9

Language

English

Region

United States

NLM ID

0370626

PMCID

PMC1434923

Subset

Grants

NHLBI NIH HHS · HL21922 · United States

External Links

PubMed source DOI: 10.1016/S0006-3495(84)84227-7 PMC Full Text View journal details

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Delayed rectification in the cardiac Purkinje fiber is not activated by intracellular calcium.

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