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PMID: 6717565 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats.

Nature ·Vol. 308 ·No. 5961 ·1984-00-00 ·Pages 705-9

Schmale H, Richter D

Abstract

In rats with hereditary hypothalamic diabetes insipidus (Brattleboro rats) the gene for the vasopressin precursor lacks a single G residue in the protein-coding region. The mutation gives rise to an open reading frame predicting a hormone precursor having a different C-terminus.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Chromosome Deletion Diabetes Insipidus/genetics Genes Hypothalamus/metabolism Liver/metabolism Mutation Nucleic Acid Hybridization Protein Biosynthesis RNA, Messenger/genetics Rabbits Rats Rats, Brattleboro/genetics Rats, Mutant Strains/genetics Reticulocytes/metabolism Vasopressins/genetics

Chemicals

RNA, Messenger Vasopressins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Schmale H

Richter D

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/308705a0

Published

1984-00-00

Pages

705-9

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

L00106, L00107, V01275, V01276, X00510, X01637

External Links

PubMed source DOI: 10.1038/308705a0 View journal details

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Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats.

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