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题目:: Monoclonal antibody ECCD-1 inhibits intercellular communication in teratocarcinoma PCC3 cells.
作者:: Kanno(Y),Sasaki(Y),Shiba(Y),Yoshida-Noro(C),Takeichi(M)
状态:: 发布时间1984-06-05 , 更新时间 2015-11-19
期刊:: Exp Cell Res
摘要:: The monoclonal antibody ECCD-1 recognizing a certain class of cell surface proteins inhibits the Ca2+-dependent cell-to-cell adhesion in teratocarcinoma stem cells. In this paper, we studied the effect of ECCD-1 on cell-to-cell communication in PCC3 cells by measuring the transfer of lucifer yellow between cells. To this aim, PCC3 cells were cultured in the presence of ECCD-1 for various periods, and then the fluorescent dye was injected into a cell located in the center of cell colonies, followed by counting number of cells to which the dye was transferred. The results showed that ECCD-1 inhibits the dye transfer between cells, suggesting that the Ca2+-dependent cell-to-cell adhesion system (CDS) is essential for the functions of gap junction.
语言:: eng
DOI:

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