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PMID: 6704143 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Haemolytic activity of aromatic heptaenes. A group of polyene macrolide antifungal antibiotics.

Biochemical pharmacology ·Vol. 33 ·No. 1 ·1984-01-01 ·Pages 41-6

Cybulska B, Mazerski J, Borowski E, Gary-Bobo CM

Abstract

The aromatic heptaene vacidin A induces ion selective channels in human red blood cells. The ion flux induced leads to a secondary effect--colloid osmotic haemolysis. Molecular variations at ionizable polar groups of the antibiotic modify the properties of the permeability pathway concerning intercationic selectivity and the symmetry of ion flux.

MeSH Terms

Antifungal Agents/pharmacology Candicidin/analogs & derivatives,pharmacology Dose-Response Relationship, Drug Erythrocytes/drug effects Hemolysis Humans Osmosis/drug effects Potassium/blood Sodium/blood Time Factors

Chemicals

Antifungal Agents Candicidin vacidin A Sodium Potassium

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Cybulska B

Mazerski J

Borowski E

Gary-Bobo C M

Article Info

Journal

Biochemical pharmacology

Abbr.

Biochem Pharmacol

ISSN

0006-2952

DOI

10.1016/0006-2952(84)90368-x

Published

1984-01-01

Pages

41-6

Language

English

Region

England

NLM ID

0101032

Subset

External Links

PubMed source DOI: 10.1016/0006-2952(84)90368-x View journal details

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Haemolytic activity of aromatic heptaenes. A group of polyene macrolide antifungal antibiotics.

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