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PMID: 6698206
Published · ppublish
English
Journal Article
The organ uptake of intravenously administered colloidal particles can be altered using a non-ionic surfactant (Poloxamer 338).
Abstract
Small polystyrene particles coated with a high Mr non-ionic surfactant (Poloxamer 338) are diverted from the reticuloendothelial system of the liver and spleen to other tissue sites. These results are discussed in terms of the adsorption of the Poloxamer to the particle surface and the implications for drug targeting.
MeSH Terms
Animals
Colloids
Injections, Intravenous
Liver/metabolism
Mononuclear Phagocyte System/metabolism
Poloxalene/pharmacology
Polyethylene Glycols/pharmacology
Rabbits
Spleen/metabolism
Tissue Distribution
Chemicals
Colloids
Polyethylene Glycols
Poloxalene
Article Info
Journal
FEBS letters
Abbr.
FEBS Lett
ISSN
0014-5793
Published
1984-02-13
Pages
79-82
Language
English
Region
England
NLM ID
0155157
Subset
IM
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