Assignment of NADH-cytochrome b5 reductase (DIA1 locus) to human chromosome 22.
NADH-cytochrome b5 reductase (DIA1, EC. 1.6.2.2) from human fibroblasts and from Chinese hamster cells, both identified by immunologic studies, were clearly distinguished after polyacrylamide gel isoelectro-focusing followed by staining for NADH diaphorase activity. In thirteen independent man-hamster hybrids, the human enzyme DIA1 presented a positive correlation with the human chromosome G22. Eight hybrids were DIA1(+) G22(+) and five hybrids were DIA1(-) G22(-). These data agree with the recent assignment of DIA1 to chromosome G22 by Fisher et al. (1977a). We assume that this newly assigned locus codes for both soluble and microsomal forms of NADH-cytochrome b5 reductase.
17 references, click to expand
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Assignment of the DIA1 locus to chromosome 22.Ann Hum Genet. 1977 Oct;41(2):151-5 PMID: 596823
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The separation of human and animal hemoglobins by isoelectric focusing in polyacrylamide gel.Biochim Biophys Acta. 1971 Jan 19;229(1):42-50 PMID: 5543619
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An interpretation of human diaphorase isozymes in terms of three gene loci DIA1, DIA2 and DIA3.Ann Hum Genet. 1977 Oct;41(2):139-49 PMID: 563699
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Immunological similarity between NADH-cytochrome b5 reductase of erythrocytes and liver microsomes.Biochim Biophys Acta. 1976 Feb 16;423(2):293-302 PMID: 2319
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Studies on methemoglobin reductase. Immunochemical similarity of soluble methemoglobin reductase and cytochrome b5 of human erythrocytes with NADH-cytochrome b5 reductase and cytochrome b5 of rat liver microsomes.Arch Biochem Biophys. 1976 Feb;172(2):600-7 PMID: 1259422
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Presence of red cell type NADH-methemoglobin reductase (NADH-diaphorase) in human non erythroid cells.Biochem Biophys Res Commun. 1972 Nov 15;49(4):945-50 PMID: 4404857
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