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PMID: 6693017 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Regenerating rat liver: correlations between estrogen receptor localization and deoxyribonucleic acid synthesis.

Gastroenterology ·Vol. 86 ·No. 3 ·1984-03-00 ·Pages 552-7

Francavilla A, di Leo A, Eagon PK, Wu SQ, Ove P, van Thiel DH, Starzl TE

Abstract

Estrogen receptor activity was quantitated in the cytosol and nucleus of normal rat liver and in regenerating rat liver at several time intervals after 75% hepatectomy. Cytosolic estradiol binding in regenerating liver decreases at 12, 24, and 48 h after hepatectomy and at 48 h is 30% of that in normal rat liver. Nuclear estrogen binding 48 h after surgery is elevated fivefold over normal values. No alterations in affinity of the receptor for estrogen have been observed. Specificity studies indicate that the estrogen receptors from both normal and regenerating liver were similar and are highly specific for estrogens. These changes in cellular distribution of receptors parallel increases in nuclear deoxyribonucleic acid synthesis and mitotic indices in the liver.

MeSH Terms
Animals Cell Nucleus/metabolism Cytosol/metabolism DNA/biosynthesis Estradiol/metabolism Estriol/metabolism Estrone/metabolism Liver/metabolism Liver Regeneration Male Mitotic Index Rats Rats, Inbred Strains Receptors, Estrogen/metabolism
Chemicals
Receptors, Estrogen Estrone Estradiol DNA Estriol
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Francavilla A
di Leo A
Eagon P K
Wu S Q
Ove P
van Thiel D H
Starzl T E
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33 references, click to expand
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Article Info
Journal
Gastroenterology
Abbr.
Gastroenterology
ISSN
0016-5085
Published
1984-03-00
Pages
552-7
Language
English
Region
United States
NLM ID
0374630
PMCID
PMC2974266
Subset
IM
Grants
NCRR NIH HHS · RR-000084 · United States
NIDDK NIH HHS · R01 DK029961-19 · United States
NIADDK NIH HHS · AM-29961 · United States
NCRR NIH HHS · M01 RR000084 · United States
NIADDK NIH HHS · AM-30001 · United States
External Links
PubMed source PMC Full Text View journal details
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