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PMID: 6691143 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Mapping of the human Blym-1 transforming gene activated in Burkitt lymphomas to chromosome 1.

Science (New York, N.Y.) ·Vol. 223 ·No. 4632 ·1984-01-13 ·Pages 173-5

Morton CC, Taub R, Diamond A, Lane MA, Cooper GM, Leder P

Abstract

Blym-1, a transforming gene detected by transfection of NIH 3T3 cells with DNA from Burkitt lymphomas, was mapped to the short arm of chromosome 1 (1p32) by chromosomal in situ hybridization. The Blym-1 gene was not physically linked to the cellular myc oncogene or to any of the immunoglobulin gene loci implicated in the characteristic chromosomal translocations in Burkitt lymphoma.

MeSH Terms

Base Sequence Burkitt Lymphoma/genetics Chromosome Aberrations Chromosome Mapping Chromosomes, Human, 1-3 Genetic Linkage Humans Immunoglobulins/genetics Male Nucleic Acid Hybridization Oncogenes Translocation, Genetic

Chemicals

Immunoglobulins

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Morton C C

Taub R

Diamond A

Lane M A

Cooper G M

Leder P

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6691143

Published

1984-01-13

Pages

173-5

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NCI NIH HHS · CA-21082 · United States

NCI NIH HHS · CA-33108 · United States

NIGMS NIH HHS · GM-17088 · United States

External Links

PubMed source DOI: 10.1126/science.6691143 View journal details

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Mapping of the human Blym-1 transforming gene activated in Burkitt lymphomas to chromosome 1.

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