The polymorphism of the vitamin D-binding protein (Gc); isoelectric focusing in 3 M urea as additional method for identification of genetic variants.

Human genetics ·Vol. 65 ·No. 2 ·1983-00-00 ·Pages 176-80

Constans J, Cleve H, Dykes D, Fischer M, Kirk RL, Papiha SS, Scheffran W, Scherz R, Thymann M, Weber W

Abstract

Since the last report numerous new DBP (Gc) variants have been observed; at present a total of 84 different mutants can be distinguished. Several of them have similar electrophoretic mobilities and/or isoelectric points of conventional isoelectric focusing (IEF). IEF in polyacrylamide gels in the presence of 3 M urea is a convenient and efficient method for the detection of hidden variation.

MeSH Terms

Carrier Proteins/genetics Genetic Variation Humans Isoelectric Focusing Phenotype Polymorphism, Genetic Urea/analysis Vitamin D-Binding Protein

Chemicals

Carrier Proteins Vitamin D-Binding Protein Urea

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Constans J

Cleve H

Dykes D

Fischer M

Kirk R L

Papiha S S

Scheffran W

Scherz R

Thymann M

Weber W

References (11)

11 references, click to expand

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Population genetics of the group specific component (Gc) and phosphoglucomutase (PGM1) studied by isoelectric focusing.
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Distribution of Hp, Tf, Gc and Pi polymorphisms in a Nepalese population.
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Five new Gc variants detected by isoelectric focusing in agarose gel.
Hum Genet. 1982;60(4):340-3 PMID: 6179851
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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00286658

Published

1983-00-00

Pages

176-80

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00286658 View journal details

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The polymorphism of the vitamin D-binding protein (Gc); isoelectric focusing in 3 M urea as additional method for identification of genetic variants.

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