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PMID: 6672692 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The major calmodulin-stimulated phosphoprotein of synaptic junctions and the major post-synaptic density protein are distinct.

Neuroscience letters ·Vol. 43 ·No. 2-3 ·1983-12-30 ·Pages 161-5

Rostas JA, Brent VA, Dunkley PR

Abstract

The major post-synaptic density protein (mPSDp) present in isolated synaptic junction fractions is distinct from the major phosphoprotein (50Kpp) that is labelled by an endogenous calmodulin-stimulated protein kinase. mPSDp and the 50Kpp have different apparent molecular weights on sodium dodecyl sulphate polyacrylamide gels and the presence of 50Kpp in brain soluble fractions indicates that the two proteins have different subcellular distributions.

MeSH Terms

Animals Calmodulin/metabolism Cerebral Cortex/enzymology Electrophoresis, Polyacrylamide Gel Male Membrane Proteins/metabolism Molecular Weight Nerve Tissue Proteins/metabolism Phosphoproteins/metabolism Phosphorylation Protein Kinases/metabolism Rats Rats, Inbred Strains Stimulation, Chemical Synapses/enzymology Synaptic Membranes/enzymology

Chemicals

Calmodulin Membrane Proteins Nerve Tissue Proteins Phosphoproteins postsynaptic density proteins Protein Kinases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Rostas J A

Brent V A

Dunkley P R

Article Info

Journal

Neuroscience letters

Abbr.

Neurosci Lett

ISSN

0304-3940

DOI

10.1016/0304-3940(83)90181-7

Published

1983-12-30

Pages

161-5

Language

English

Region

Ireland

NLM ID

7600130

Subset

External Links

PubMed source DOI: 10.1016/0304-3940(83)90181-7 View journal details

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The major calmodulin-stimulated phosphoprotein of synaptic junctions and the major post-synaptic density protein are distinct.

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