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PMID: 6654341 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cystic fibrosis in the Ohio Amish: gene frequency and founder effect.

Human genetics ·Vol. 65 ·No. 2 ·1983-00-00 ·Pages 94-8

Klinger KW

Abstract

A high incidence of cystic fibrosis (CF), 1/569 live births (0.00176), was found among 10 816 live births in an Ohio Amish isolate. The minimum gene frequency calculated from this incidence was 0.042. In marked contrast, a second Amish isolate was described with no occurrence of CF among 4448 live births. Founder effect is the most probable explanation for the difference in the CF gene frequency between the two communities. Pedigree analysis identified a single ancestral couple born in the 1700s common to all obligate heterozygotes.

MeSH Terms
Cystic Fibrosis/epidemiology,genetics Female Gene Frequency Heterozygote Humans Male Ohio Pedigree
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Klinger K W
References (10)
10 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00286641
Published
1983-00-00
Pages
94-8
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00286641 View journal details
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