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PMID: 6652378 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Opiate activation of potassium conductance inhibits calcium action potentials in rat locus coeruleus neurones.

British journal of pharmacology ·Vol. 80 ·No. 2 ·1983-10-00 ·Pages 225-8

North RA, Williams JT

Abstract

Opiates act on mu-receptors to increase the potassium conductance of rat locus coeruleus neurones. Opiates also depress the rate of rise and peak amplitude of calcium action potentials in these cells. The action of opiates on calcium action potentials was prevented by two procedures which blocked the opiate-induced potassium current, intracellular caesium and extracellular barium. This indicates that the opiate reduction in calcium entry is secondary to an increased potassium current.

MeSH Terms
Action Potentials/drug effects Animals Calcium/physiology In Vitro Techniques Locus Coeruleus/drug effects,physiology Narcotics/pharmacology Potassium/physiology Rats Tetrodotoxin/pharmacology
Chemicals
Narcotics Tetrodotoxin Potassium Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
North R A
Williams J T
References (11)
11 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1983.tb10023.x
Published
1983-10-00
Pages
225-8
Language
English
Region
England
NLM ID
7502536
PMCID
PMC2045013
Subset
IM
Grants
NIDA NIH HHS · DA03161 · United States
External Links
PubMed source DOI: 10.1111/j.1476-5381.1983.tb10023.x PMC Full Text View journal details
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