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PMID: 6627809 Published · ppublish English Journal Article

Interindividual variations in drug disposition. Clinical implications and methods of investigation.

Clinical pharmacokinetics ·Vol. 8 ·No. 5 ·1983-00-00 ·Pages 371-7

Breimer DD

Abstract

暂无摘要

MeSH Terms
Animals Antipyrine/metabolism Humans Individuality Metabolic Clearance Rate Oxidation-Reduction Pharmaceutical Preparations/metabolism Rats
Chemicals
Pharmaceutical Preparations Antipyrine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Breimer D D
References (28)
28 references, click to expand
  1. The antipyrine test in clinical pharmacology: conceptions and misconceptions.
    Clin Pharmacol Ther. 1979 Sep;26(3):275-86 PMID: 111889
  2. Assessment of methods to identify sources of interindividual pharmacokinetic variations.
    Clin Pharmacokinet. 1983 Sep-Oct;8(5):378-409 PMID: 6194927
  3. Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity.
    J Pharmacol Exp Ther. 1982 Jan;220(1):120-6 PMID: 7053408
  4. Induction of hexobarbital and antipyrine metabolism by rifampicin treatment in the pig.
    Drug Metab Dispos. 1981 Nov-Dec;9(6):541-4 PMID: 6120813
  5. 3-Hydroxymethyl antipyrine excretion in urine after an oral dose of antipyrine. A reconsideration of previously published data and synthesis of a pure reference substance.
    Pharmacology. 1982;24(3):181-4 PMID: 7071130
  6. Comparison of the in vivo and in vitro rates of formation of the three main oxidative metabolites of antipyrine in man.
    Br J Clin Pharmacol. 1981 Dec;12(6):771-7 PMID: 7340879
  7. Genetic variation in rates of antipyrine metabolite formation: a study in uninduced twins.
    Proc Natl Acad Sci U S A. 1981 Aug;78(8):5193-6 PMID: 6946467
  8. Polymorphisms of oxidation at carbon centers of drugs and their clinical significance.
    Drug Metab Rev. 1979;9(2):301-17 PMID: 158499
  9. Ethnic differences in drug metabolism.
    Clin Pharmacokinet. 1982 Sep-Oct;7(5):373-400 PMID: 6754206
  10. E- and Z-10-hydroxylation of nortriptyline: relationship to polymorphic debrisoquine hydroxylation.
    Clin Pharmacol Ther. 1981 Aug;30(2):189-93 PMID: 7249504
  11. Defective oxidation of drugs: pharmacokinetic and therapeutic implications.
    Clin Pharmacokinet. 1982 Jan-Feb;7(1):1-22 PMID: 7042170
  12. Individual differences in the disposition of drugs metabolised in the body.
    Clin Pharmacokinet. 1978 Mar-Apr;3(2):155-75 PMID: 346288
  13. Environmental effects on antipyrine half-life in man.
    Clin Pharmacol Ther. 1977 Nov;22(5 Pt 2):799-808 PMID: 913037
  14. Environmental factors affecting antipyrine metabolism in London factory and office workers.
    Br J Clin Pharmacol. 1979 Mar;7(3):237-43 PMID: 427001
  15. Differential induction of antipyrine metabolism by rifampicin.
    Eur J Clin Pharmacol. 1981;21(2):155-60 PMID: 7341283
  16. Intraindividual variation in drug disposition.
    Clin Pharmacol Ther. 1979 Oct;26(4):407-19 PMID: 314881
  17. Assay of antipyrine and its primary metabolites in plasma, saliva and urine by high-performance liquid chromatography and some preliminary results in man.
    Pharmacology. 1979;18(4):210-23 PMID: 461498
  18. Family study of antipyrine clearance.
    Br Med J (Clin Res Ed). 1982 Jan 16;284(6310):150-2 PMID: 6799075
  19. Interindividual differences in drug oxidation: clinical importance.
    Drug Metab Dispos. 1973 Jan-Feb;1(1):469-82 PMID: 4149420
  20. Factors affecting theophylline clearances: age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol.
    J Pharm Sci. 1979 Nov;68(11):1358-66 PMID: 41932
  21. A case of deficiency of N-hydroxylation of amobarbital.
    Clin Pharmacol Ther. 1977 May;21(5):530-5 PMID: 558078
  22. Studies of the different metabolic pathways of antipyrine in man. Oral versus i.v. administration and the influence of urinary collection time.
    Eur J Clin Pharmacol. 1982;21(5):433-41 PMID: 7075648
  23. Influence of the genetically controlled deficiency in debrisoquine hydroxylation on antipyrine metabolite formation.
    Pharmacology. 1981;22(6):349-58 PMID: 7267701
  24. Factors affecting antipyrine metabolism in West African villagers.
    Clin Pharmacol Ther. 1976 Sep;20(3):369-76 PMID: 954356
  25. Pharmacokinetics of simultaneously administered hexobarbital and heptabarbital in rats: an alternative approach to metabolic correlation studies.
    J Pharmacol Exp Ther. 1983 Jun;225(3):747-51 PMID: 6134816
  26. Multiplicity of mammalian microsomal cytochromes P-45.
    Pharmacol Rev. 1979 Dec;31(4):277-95 PMID: 399809
  27. Genetic and environmental factors affecting drug disposition in man.
    Clin Pharmacol Ther. 1977 Nov;22(5 Pt 2):659-79 PMID: 334437
  28. Antipyrine metabolism in the rat by three hepatic monooxygenases.
    Life Sci. 1980 Jun 9;26(23):1977-83 PMID: 7401910
Article Info
Journal
Clinical pharmacokinetics
Abbr.
Clin Pharmacokinet
ISSN
0312-5963
Published
1983-00-00
Pages
371-7
Language
English
Region
Switzerland
NLM ID
7606849
Subset
IM
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