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PMID: 6623064 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye.

Science (New York, N.Y.) ·Vol. 222 ·No. 4620 ·1983-10-14 ·Pages 169-72

Bernal SD, Lampidis TJ, McIsaac RM, Chen LB

Abstract

Carcinoma cells and normal epithelial cells differ in the mitochondrial retention of a permeant cationic compound, rhodamine 123. The possibility of utilizing this difference in carcinoma chemotherapy was investigated. Rhodamine 123 exhibited anticarcinoma activity in mice, and this activity was potentiated by 2-deoxyglucose.

MeSH Terms

Animals Carcinoma/drug therapy Carcinoma, Ehrlich Tumor/drug therapy Cell Line Deoxyglucose/therapeutic use Drug Synergism Drug Therapy, Combination Energy Metabolism/drug effects Mice Mitochondria/drug effects Rhodamine 123 Rhodamines/therapeutic use Urinary Bladder Neoplasms/drug therapy Xanthenes/therapeutic use

Chemicals

Rhodamines Xanthenes Rhodamine 123 Deoxyglucose

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Bernal S D

Lampidis T J

McIsaac R M

Chen L B

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6623064

Published

1983-10-14

Pages

169-72

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NCI NIH HHS · CA22427 · United States

NCI NIH HHS · CA29793 · United States

NCI NIH HHS · CA33847 · United States

External Links

PubMed source DOI: 10.1126/science.6623064 View journal details

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Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye.

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