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PMID: 6611353 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Catecholamines are mitogenic in 3T3 and bovine aortic endothelial cells.

The Journal of clinical investigation ·Vol. 74 ·No. 2 ·1984-08-00 ·Pages 483-7

Sherline P, Mascardo R

Abstract

We have found that catecholamines stimulate DNA synthesis and centrosomal separation in 3T3 and bovine aortic endothelial cells cultured in the absence of serum or added growth factors. The mitogenic effect is mediated by an alpha 1-adrenergic receptor, as it is inhibited by phentolamine and prazosin but not by propranolol or yohimbine. The physiological and pathological consequences of this effect remain to be determined.

MeSH Terms
Animals Aorta/physiology Cattle Cell Cycle/drug effects Cells, Cultured DNA Replication/drug effects Endothelium/drug effects,physiology Epidermal Growth Factor/pharmacology Epinephrine/pharmacology Kinetics Mice Mitogens Prazosin/pharmacology Yohimbine/pharmacology
Chemicals
Mitogens Yohimbine Epidermal Growth Factor Prazosin Epinephrine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sherline P
Mascardo R
References (17)
17 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI111445
Published
1984-08-00
Pages
483-7
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC370500
Subset
IM
Grants
NIGMS NIH HHS · GM-22497 · United States
External Links
PubMed source DOI: 10.1172/JCI111445 PMC Full Text View journal details
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