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题目:: Phenotypical heterogeneity of Japanese adult T-cell leukaemia.
作者:: Tagawa(S),Konishi(I),Tokumine(Y),Kuratsune(H),Machii(T),Kitani(T)
状态:: 发布时间1984-04-25 , 更新时间 2004-11-17
期刊:: Scand J Haematol
摘要:: The leukaemic cells of 11 patients with Japanese adult T-cell leukaemia (ATL) were characterized in terms of phenotype employing various monoclonal antibodies against T-cell surface antigens. The leukaemic cells of all ATL patients except patient no. 11 displayed the phenotype OKT4+/OKT8-. However, the % of OKT3+ cells varied from 3 to 98. In 1 case, cells with phenotype OKT4+/OKT8+, which is characteristic of T-cells at an early stage of differentiation, were found. These results suggest that some ATL cells may be in an immature differentiation stage. Among the 11 patients, 2 with unusual ATL cell phenotypes (1 case with OKT3- cells and 1 case with Ia+/EAC+ cells) showed spontaneous regression of leukaemic cells. Characterization of leukaemic cells from a larger number of ATL patients may demonstrate a significant relationship between cell phenotype and prognosis.
语言:: eng
DOI:

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