Cytokines and the chronic inflammation of rheumatic disease. I. The presence of interleukin-1 in synovial fluids.

Clinical and experimental immunology ·Vol. 55 ·No. 2 ·1984-02-00 ·Pages 295-302

Nouri AM, Panayi GS, Goodman SM

Abstract

Synovial fluids from patients with rheumatoid arthritis (13 cases), ankylosing spondylitis (six), psoriatic arthritis (two), osteoarthritis (three) and rubella arthritis (four) contain interleukin-1 (Il-1) activity as measured in the CH3/He mouse thymocyte assay. That this activity is Il-1 was shown by: (i) the time course of thymocyte stimulation; (ii) failure of PHA blast cells to absorb out the activity; (iii) molecular weight of 15,000-20,000 daltons, and (iv) ability to stimulate prostaglandin E2 production from synovial cells. These results indicate that IL-1 is an important mediator in the inflammatory pathway of different types of joint disease.

MeSH Terms

Animals Arthritis/immunology Arthritis, Rheumatoid/immunology Cell Division Chromatography, Gel Dinoprostone Humans Interleukin-1/analysis Lymphocyte Activation Mice Molecular Weight Osteoarthritis/immunology Prostaglandins E/biosynthesis Spondylitis, Ankylosing/immunology Synovial Fluid/immunology T-Lymphocytes/immunology Time Factors

Chemicals

Interleukin-1 Prostaglandins E Dinoprostone

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Nouri A M

Panayi G S

Goodman S M

References (13)

13 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1984-02-00

Pages

295-302

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1535803

Subset

External Links

PubMed source PMC Full Text View journal details

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Cytokines and the chronic inflammation of rheumatic disease. I. The presence of interleukin-1 in synovial fluids.

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