In vitro susceptibility of Mycobacterium fortuitum to amoxicillin or cephalothin in combination with clavulanic acid.

Antimicrobial agents and chemotherapy ·Vol. 23 ·No. 6 ·1983-06-00 ·Pages 935-7

Cynamon MH, Palmer GS

Abstract

The comparative in vitro activity of cefoxitin, cephalothin, amoxicillin, and clavulanic acid in combination with the latter two agents against 13 isolates of Mycobacterium fortuitum was evaluated by agar dilution susceptibility testing. Amoxicillin was more active than cephalothin but less active than cefoxitin against the strains tested. Clavulanic acid in combination with these beta-lactams usually improved the activity by one or two dilutions compared with the beta-lactams alone.

MeSH Terms

Amoxicillin/pharmacology Cephalothin/pharmacology Clavulanic Acids/administration & dosage Drug Combinations Microbial Sensitivity Tests Mycobacterium/drug effects Nontuberculous Mycobacteria/drug effects beta-Lactamases/analysis

Chemicals

Clavulanic Acids Drug Combinations Amoxicillin beta-Lactamases Cephalothin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Cynamon M H

Palmer G S

References (7)

7 references, click to expand

In vitro activity of temocillin (BRL 17421), a novel beta-lactamase-stable penicillin.
Antimicrob Agents Chemother. 1982 Jul;22(1):157-61 PMID: 6982023
In vitro susceptibility of Mycobacterium fortuitum to N-formimidoyl thienamycin and several cephamycins.
Antimicrob Agents Chemother. 1982 Dec;22(6):1079-81 PMID: 6961887
Properties of beta-lactamases produced by three species of mycobacteria.
Biochem J. 1968 May;107(5):675-82 PMID: 16742589
Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate.
Antimicrob Agents Chemother. 1972 Apr;1(4):283-8 PMID: 4208895
Description and classification of the newer cephalosporins and their relationships with the established compounds.
J Antimicrob Chemother. 1979 Nov;5(6):635-71 PMID: 119786
In vitro susceptibility of Mycobacterium fortuitum to cefoxitin.
Antimicrob Agents Chemother. 1981 Jan;19(1):205-7 PMID: 7247358
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
Anal Biochem. 1976 May 7;72:248-54 PMID: 942051

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.23.6.935

Published

1983-06-00

Pages

935-7

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC185011

Subset

External Links

PubMed source DOI: 10.1128/AAC.23.6.935 PMC Full Text View journal details

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In vitro susceptibility of Mycobacterium fortuitum to amoxicillin or cephalothin in combination with clavulanic acid.

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