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PMID: 6603658 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Corticotropin releasing factor decreases postburst hyperpolarizations and excites hippocampal neurons.

Science (New York, N.Y.) ·Vol. 221 ·No. 4613 ·1983-08-26 ·Pages 875-7

Aldenhoff JB, Gruol DL, Rivier J, Vale W, Siggins GR

Abstract

Corticotropin releasing factor in concentrations of 15 to 250 nanomoles per liter increased the spontaneous discharge frequency and decreased the size of hyperpolarizations after burst discharges in CA1 and CA3 pyramidal neurons of rat hippocampal slices. Concentrations greater than 250 nanomoles per liter also depolarized the cells. These excitatory actions of corticotropin releasing factor may involve a novel calcium-dependent process.

MeSH Terms

Action Potentials/drug effects Animals Corticotropin-Releasing Hormone/pharmacology Hippocampus/drug effects,physiology In Vitro Techniques Membrane Potentials/drug effects Rats

Chemicals

Corticotropin-Releasing Hormone

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Aldenhoff J B

Gruol D L

Rivier J

Vale W

Siggins G R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6603658

Published

1983-08-26

Pages

875-7

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIAAA NIH HHS · AA 03504 · United States

NIADDK NIH HHS · AM 26741 · United States

External Links

PubMed source DOI: 10.1126/science.6603658 View journal details

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Corticotropin releasing factor decreases postburst hyperpolarizations and excites hippocampal neurons.

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