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PMID: 6598803 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Inhibition of plasma membrane NADH dehydrogenase by adriamycin and related anthracycline antibiotics.

Journal of bioenergetics and biomembranes ·Vol. 16 ·No. 3 ·1984-06-00 ·Pages 209-21

Sun IL, Crane FL, Löw H, Grebing C

Abstract

Doxorubicin (adriamycin) is cytotoxic to cells, but the biochemical basis for this effect is unknown, although intercalation with DNA has been proposed This study suggests that the cytotoxicity of this drug may be due to inhibition of the plasma membrane redox system, which is involved in the control of cellular growth. Concentrations between 10(-6) - 10(-7) M adriamycin inhibit plasma membrane redox reactions greater than 50%. AD32, a form of adriamycin which does not intercalate with DNA, but is cytotoxic, also inhibits the plasma membrane redox system. Thus, the cytotoxic effects of adriamycin, which limit its use as a drug, may be based on the inhibition of a transplasma membrane dehydrogenase involved in a plasma membrane redox system.

MeSH Terms
Animals Antibiotics, Antineoplastic Cell Division/drug effects Cell Membrane/enzymology Cytochrome Reductases/antagonists & inhibitors Doxorubicin/pharmacology Liver/enzymology Mice NADH Dehydrogenase/antagonists & inhibitors NADH, NADPH Oxidoreductases/antagonists & inhibitors Naphthacenes/pharmacology Structure-Activity Relationship Swine
Chemicals
Antibiotics, Antineoplastic Naphthacenes Doxorubicin NADH, NADPH Oxidoreductases Cytochrome Reductases ferricyanide reductase NADH Dehydrogenase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sun I L
Crane F L
Löw H
Grebing C
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Article Info
Journal
Journal of bioenergetics and biomembranes
Abbr.
J Bioenerg Biomembr
ISSN
0145-479X
DOI
10.1007/BF00751050
Published
1984-06-00
Pages
209-21
Language
English
Region
United States
NLM ID
7701859
Subset
IM
Grants
NIGMS NIH HHS · GMK6-21839 · United States
External Links
PubMed source DOI: 10.1007/BF00751050 View journal details
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