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PMID: 6582499 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Cell cycle regulation of human histone H1 mRNA.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 2 ·1984-01-00 ·Pages 434-8

Plumb M, Marashi F, Green L, Zimmerman A, Zimmerman S, Stein J, Stein G

Abstract

A cloned genomic DNA fragment containing a human histone H1 gene has been used to analyze histone H1 gene expression in two human cell lines (HeLa S3 and WI-38). The cellular abundance of histone H1 mRNA was compared with that of core (H2A, H2B, H3, and H4) histone mRNAs as a function of the cell cycle: core and H1 histone mRNA levels are related both to each other and to the apparent rate of DNA synthesis and are rapidly destabilized after DNA synthesis inhibition. The use of three synchronization protocols, and of transformed and normal diploid cells in culture, suggests that the detected core and H1 histone mRNA levels are regulated by similar mechanisms in continuously dividing human cell lines and nondividing cells stimulated to proliferate.

MeSH Terms
Cell Cycle Cells, Cultured Gene Expression Regulation Histones/genetics Humans Kinetics RNA, Messenger/genetics Transcription, Genetic
Chemicals
Histones RNA, Messenger
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Plumb M
Marashi F
Green L
Zimmerman A
Zimmerman S
Stein J
Stein G
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30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.81.2.434
Published
1984-01-00
Pages
434-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC344691
Subset
IM
Grants
NIGMS NIH HHS · GM32010 · United States
External Links
PubMed source DOI: 10.1073/pnas.81.2.434 PMC Full Text View journal details
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