The influence of changes in tension on protein synthesis and prostaglandin release in isolated rabbit muscles.

The Biochemical journal ·Vol. 214 ·No. 3 ·1983-09-15 ·Pages 1011-4

Palmer RM, Reeds PJ, Atkinson T, Smith RH

Abstract

Intermittent stretching of isolated rabbit muscles increased the rate of protein synthesis by 70% and prostaglandin-F2 alpha release by 105%. Both effects of intermittent stretching were blocked by indomethacin and meclofenamate; the absence of Ca2+ together with added EGTA also inhibited both processes. The residual influence of intermittent stretching on protein synthesis was closely correlated with prostaglandin-F2 alpha release, which may be the link between mechanical activity and protein synthesis in skeletal muscle.

MeSH Terms

Animals Calcium/metabolism Dinoprost In Vitro Techniques Indomethacin/pharmacology Meclofenamic Acid/pharmacology Muscle Contraction Muscle Proteins/biosynthesis Muscles/drug effects,metabolism Prostaglandins F/metabolism Rabbits

Chemicals

Muscle Proteins Prostaglandins F Meclofenamic Acid Dinoprost Calcium Indomethacin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Palmer R M

Reeds P J

Atkinson T

Smith R H

References (12)

12 references, click to expand

Role of phospholipase A2 in prostaglandin formation.
Adv Prostaglandin Thromboxane Res. 1978;3:89-95 PMID: 350023
Prostaglandins and thromboxanes.
Annu Rev Biochem. 1978;47:997-1029 PMID: 209733
[An indirect proof of stretch-induced Ca++ release from the sarcoplasmic reticulum in glycerinated skeletal and heart muscle preparations (author's transl)].
Basic Res Cardiol. 1979 Mar-Apr;74(2):177-202 PMID: 475725
Protein and collagen synthesis in rat diaphragm muscle incubated in vitro: the effect of alterations in tension produced by electrical or mechanical means.
Int J Biochem. 1980;11(1):7-14 PMID: 7353715
Prostaglandins and exercise hyperemia of dog skeletal muscle.
Am J Physiol. 1980 Feb;238(2):H191-5 PMID: 7361912
Intracellular phospholipases A.
Biochim Biophys Acta. 1980 Sep 30;604(2):191-246 PMID: 6252969
The effect of intermittent changes in tension on protein and collagen synthesis in isolated rabbit muscles.
Biochem J. 1981 Sep 15;198(3):491-8 PMID: 7326016
Arachidonic acid, prostaglandin E2 and F2 alpha influence rates of protein turnover in skeletal and cardiac muscle.
J Biol Chem. 1982 Feb 25;257(4):1632-8 PMID: 6799511
Prostaglandin synthesis in human skeletal muscle and kidney microsomes: formation of substantial amounts of an unknown, polar compound.
Acta Physiol Scand. 1981 Dec;113(4):557-9 PMID: 7348040
Regulation of prostaglandin biosynthesis in cultured cells.
Am J Physiol. 1982 Nov;243(5):C205-11 PMID: 6291399
Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (interleukin-1). A mechanism for the increased degradation of muscle proteins during fever.
N Engl J Med. 1983 Mar 10;308(10):553-8 PMID: 6402699
Protein synthesis in isolated rabbit forelimb muscles. The possible role of metabolites of arachidonic acid in the response to intermittent stretching.
Biochem J. 1983 Jul 15;214(1):153-61 PMID: 6412693

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj2141011

Published

1983-09-15

Pages

1011-4

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1152347

Subset

External Links

PubMed source DOI: 10.1042/bj2141011 PMC Full Text View journal details

Analysis Services

The influence of changes in tension on protein synthesis and prostaglandin release in isolated rabbit muscles.

Contact

WeChat Official Account