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PMID: 6572907 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Heat shock protein in mammalian brain and other organs after a physiologically relevant increase in body temperature induced by D-lysergic acid diethylamide.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 80 ·No. 2 ·1983-01-00 ·Pages 569-73

Cosgrove JW, Brown IR

Abstract

A physiologically relevant increase in body temperature from 39.7 to 42.5 degrees C, which was generated after the intravenous injection of D-lysergic acid diethylamide (LSD), caused the induction of synthesis of a 74,000-dalton heat shock protein in the brain, heart, and kidney of the young adult rabbit. A marked increase in the relative labeling of a 74,000-dalton protein was noted after analysis of both in vivo labeled proteins and cell-free translation products of isolated polysomes. A temporal decrease in the synthesis of this protein was noted as LSD-induced hyperthermia subsided. The 74,000-dalton protein, which is induced in various organs of the intact animal at a body temperature similar to that attained during fever reactions, may play a role in homeostatic control mechanisms.

MeSH Terms
Animals Body Temperature/drug effects Brain/drug effects,metabolism Electrophoresis, Polyacrylamide Gel Heat-Shock Proteins Hot Temperature Kidney/metabolism Lysergic Acid Diethylamide Male Myocardium/metabolism Organ Specificity Polyribosomes/drug effects,metabolism Protein Biosynthesis/drug effects Proteins/genetics Rabbits Radioimmunoassay
Chemicals
Heat-Shock Proteins Proteins Lysergic Acid Diethylamide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cosgrove J W
Brown I R
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.80.2.569
Published
1983-01-00
Pages
569-73
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC393421
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.80.2.569 PMC Full Text View journal details
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