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PMID: 6563877 Published · ppublish English Journal Article

Cross-resistance between methicillin and cephalosporins for staphylococci: a general assumption not true for cefamandole.

Antimicrobial agents and chemotherapy ·Vol. 25 ·No. 5 ·1984-05-00 ·Pages 666-8

Frongillo RF, Bianchi P, Moretti A, Pasticci MB, Ripa S, Pauluzzi S

Abstract

The antibacterial activity of cefamandole was evaluated against 120 methicillin-susceptible and methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococcal strains, using both large (10(8) CFU per ml) and small (10(4) CFU per ml) inocula. Cefamandole appeared superior to cephalothin against methicillin-resistant strains, displaying at 10 micrograms/ml a bacteriostatic and for some strains a bactericidal action against a large inoculum of bacteria.

MeSH Terms
Cefamandole/pharmacology Cephalosporins/pharmacology Methicillin/pharmacology Microbial Sensitivity Tests Penicillin Resistance Staphylococcus/drug effects Staphylococcus aureus/drug effects
Chemicals
Cephalosporins Cefamandole Methicillin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Frongillo R F
Bianchi P
Moretti A
Pasticci M B
Ripa S
Pauluzzi S
References (15)
15 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.25.5.666
Published
1984-05-00
Pages
666-8
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC185613
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.25.5.666 PMC Full Text View journal details
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