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PMID: 6546784 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum.

Nature ·Vol. 308 ·No. 5960 ·1984-00-00 ·Pages 613-7

Chin DJ, Gil G, Russell DW, Liscum L, Luskey KL, Basu SK, Okayama H, Berg P, Goldstein JL, Brown MS

Abstract

The nucleotide sequence of a 4.8-kilobase mRNA for hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase, the endoplasmic reticulum enzyme that controls cholesterol biosynthesis, shows that it is a protein of 887 amino acids (molecular weight 97,092) which contains three potential sites for asparagine-linked glycosylation. The reductase is a transmembrane glycoprotein, but in contrast to many other transmembrane glycoproteins, it lacks a cleavable or hydrophobic NH2-terminal signal sequence.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cell Line Cloning, Molecular Cricetinae Cricetulus DNA/metabolism Endoplasmic Reticulum/enzymology Female Glycoproteins/genetics Hydroxymethylglutaryl CoA Reductases/genetics Molecular Weight Ovary Plasmids RNA, Messenger/genetics
Chemicals
Glycoproteins RNA, Messenger DNA Hydroxymethylglutaryl CoA Reductases
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Chin D J
Gil G
Russell D W
Liscum L
Luskey K L
Basu S K
Okayama H
Berg P
Goldstein J L
Brown M S
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/308613a0
Published
1984-00-00
Pages
613-7
Language
English
Region
England
NLM ID
0410462
Subset
IM
Databases
GENBANK
L00165, L00166, L00169, L00170, L00171, L00173, L00176, L00177, L00178, L00179, L00180, L00181, L00182, L00183, X00494
External Links
PubMed source DOI: 10.1038/308613a0 View journal details
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