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PMID: 6546329 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't

Vitamin D conversion by sarcoid lymph node homogenate.

Annals of internal medicine ·Vol. 100 ·No. 1 ·1984-01-00 ·Pages 59-61

Mason RS, Frankel T, Chan YL, Lissner D, Posen S

Abstract

Recent studies suggest that hypercalcemia of sarcoidosis is due to high blood concentrations of calcitriol and that this compound may be synthesized at an extra-renal site. We report that sarcoid lymph node homogenate metabolized calcifediol to a substance indistinguishable from calcitriol, whereas six nonsarcoid lymph nodes failed to produce this compound.

MeSH Terms

Calcifediol/metabolism Calcitriol/metabolism Dihydroxycholecalciferols/metabolism Humans In Vitro Techniques Lymph Nodes/metabolism Lymphatic Diseases/metabolism Male Middle Aged Sarcoidosis/metabolism Vitamin D/metabolism

Chemicals

Dihydroxycholecalciferols Vitamin D Calcitriol Calcifediol 25,26-dihydroxycholecalciferol

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Mason R S

Frankel T

Chan Y L

Lissner D

Posen S

Article Info

Journal

Annals of internal medicine

Abbr.

Ann Intern Med

ISSN

0003-4819

DOI

10.7326/0003-4819-100-1-59

Published

1984-01-00

Pages

59-61

Language

English

Region

United States

NLM ID

0372351

Subset

External Links

PubMed source DOI: 10.7326/0003-4819-100-1-59 View journal details

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Vitamin D conversion by sarcoid lymph node homogenate.

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